Deutsch | English | Español | Français | Italiano | Português | Русский | العربية | 日本語 | 简体中文 | 繁體中文 | 한국의 | Türk | Polski
LOGO
Global B2B Portal for Bio-Medical & Pharm Industry
Product / Service Supplier Catalogs & Literature    
Search
or
home Product News Catalogs Web TV News & Topics Featured Articles Trade Shows Sourcing Help My allbiomedical
Featured Articles Content
allbiomedical > Featured Articles > Stem cell study reveals complexity of glue molecule’s role in cancer

Stem cell study reveals complexity of glue molecule’s role in cancer
Author: University of Manchester
Source From: Bioscience Technology
Posted Date: 2011-07-14

A protein molecule that ‘glues’ cells together and so has a key role in cancer is also responsible for many other important functions of cells, a new study has found. University of Manchester scientists say their unexpected findings are important because they could lead to a better understanding of why some cancer cells are difficult to eradicate in patients and lead to new cancer treatments.

The research – published in PLoS One – looked at the role of the cell-adhesion molecule E-cadherin in embryonic stem (ES) cells. As well as the expected findings associated with changes in adhesion, the team found that the protein may also regulate up to 25% of the genes within cells.

“E-cadherin is a ‘glue’ that keeps cells together in the body – without it we would not develop beyond a bundle of cells a few days after conception,” said Dr Chris Ward, who led the study in the University’s School of Dentistry.

“E-cadherin is also important during cancer progression from benign to malignant states, with loss of this molecule leading to increased movement of the cells which can lead to secondary tumours within the body.

“Whilst E-cadherin has been studied intensively there has been no research that has identified all of the genes that E-cadherin regulates. Our lab has carried out profiling of ES cells lacking E-cadherin and found this protein is responsible for regulating up to 25% of the genes within cells.

“As well as the expected findings associated with changes in cell adhesion, we found that E-cadherin exerts an effect on a diverse range of biological functions within the cell. This unexpected result demonstrates that E-cadherin, often viewed as no more than a cell ‘glue’, is an important part of regulating the biology of ES cells.”

The group found that E-cadherin regulates genes associated with, amongst other things, cell proliferation, cell death, metabolism of fats and sugars and the deciphering of messages received by cells from outside.

Since loss of E-cadherin is implicated in higher death rates in cancer patients and a more aggressive tumour type, the group has suggested that this molecule may have a much more important role to play in preventing tumour development.

Dr Ward added: “Essentially, abnormal regulation of E-cadherin can lead to a significant change in a cell and this may be one of the reasons why such cells are difficult to eradicate in cancer patients. Further investigation of specific changes in these cells may lead to the development of novel treatments for cancer.”
 

Tags:

Original Hyperlink: http://www.biosciencetechnology.com/News/Feeds/2011/07/sections-international-ne..

For more information from this magazine/website? Please click here http://www.biosciencetechnology.com

About Us:Bioscience Technology, published 12 times a year, provides 55,000 life science/biotechnology researchers with new product and new technology information on a monthly basis. Each issue contains new product information, tools and techniques articles, and specific product focused sections.

Note: The copyright and the ownship of the brand, product names, product numbers, and content mentioned belongs to their repective companies.

comments powered by Disqus
Latest News

‧2012-10-26
Green Tea and Cancer Prevention: New Clues

‧2012-10-25
Technology: Fused Deposition Modeling

‧2012-10-24
Multivitamins May Help Prevent Cancer

‧2012-09-20
iPhone Attachment Designed for At-Home Diagnoses of Ear Infections

‧2012-09-19
The Ups and Downs of Modern Laboratory Design

Related Catalogs
Featured Pages
Contents
· Home
· Product News
· Catalogs
· Web TV
· News & Topics
· Features Articles
· Trade Show
· Sourcing Help
· My Allbiomedical
Special Zone
· Directory
· Trade Show Supplement
Allbiomedical.com
· About Us
· Promote Your Business
· Advertise
· Partner with Us
· Press Release
· Contact Us
· Term of Use
· Privacy Policy
· Starter Program
· Sitemap
B2B Web Portal Alliance
· Allitwares.com
· Allmetalworking.com
· Allbiomedical.com
· Allautowares.com
Buy Engineer Sample Kits
OEM Sourcing
Language
· Deutsch
· English
· Español
· Français
· Italiano
· Português
· Русский
· العربية
· 日本語
· 简体中文
· 繁體中文
· 한국의
· Türk
· Polski
 
   

Copyrights © 2012 Allitwares Corporation All Rights Reserved. www.allbiomedical.com is a Division of Allitwares Corporation
www.allbiomedical.com is a B2B Trade Portal | B2B Web Portal |B2B Marketplace for biomedical and pharmaceutical industry